Publications

A widespread family of viral sponge proteins reveals specific inhibition of nucleotide signals in anti-phage defense

Chang RB, Toyoda HC, Hobbs SJ, Hadary R, Richmond-Buccola D, Wein T, Osterman I, Burger N, Chouchani ET, Sorek R, Kranzusch PJ.

Mol Cell. 2025 Aug 21;85(16):3151-3165.e6. PMID: 40845805

A DNA-gated molecular guard controls bacterial Hailong anti-phage defence

Tan JMJ, Melamed S, Cofsky JC, Syangtan D, Hobbs SJ, Del Mármol J, Jost M, Kruse AC, Sorek R, Kranzusch PJ.

Nature. 2025 Jul;643(8072):794-800. doi: 10.1038/s41586-025-09058-z. Epub 2025 Apr 30.PMID: 40306316

Structure-guided discovery of viral proteins that inhibit host immunity

Yirmiya E, Hobbs SJ, Leavitt A, Osterman I, Avraham C, Hochhauser D, Madhala B, Skovorodka M, Tan JMJ, Toyoda HC, Chebotar I, Itkin M, Malitsky S, Amitai G, Kranzusch PJ, Sorek R.

Cell. 2025 Mar 20;188(6):1681-1692.e17. PMID: 39855193

Nucleotide Immune Signaling in CBASS, Pycsar, Thoeris, and CRISPR Antiphage Defense

Hobbs SJ, Kranzusch PJ.

Annu Rev Microbiol. 2024 Nov;78(1):255-276. PMID: 39083849

Animal and bacterial viruses share conserved mechanisms of immune evasion

Hobbs SJ, Nomburg J, Doudna JA, Kranzusch PJ.

Cell. 2024 Oct 3;187(20):5530-5539.e8. PMID: 39197447

A large-scale type I CBASS antiphage screen identifies the phage prohead protease as a key determinant of immune activation and evasion

Richmond-Buccola D, Hobbs SJ, Garcia JM, Toyoda H, Gao J, Shao S, Lee ASY, Kranzusch PJ.

Cell Host Microbe. 2024 Jul 10;32(7):1074-1088.e5. PMID: 38917809

Phages overcome bacterial immunity via diverse anti-defence proteins

Yirmiya E, Leavitt A, Lu A, Ragucci AE, Avraham C, Osterman I, Garb J, Antine SP, Mooney SE, Hobbs SJ, Kranzusch PJ, Amitai G, Sorek R.

Nature. 2024 Jan;625(7994):352-359. PMID: 37992756

Bacterial SEAL domains undergo autoproteolysis and function in regulated intramembrane proteolysis

Brogan AP, Habib C, Hobbs SJ, Kranzusch PJ, Rudner DZ.

Proc Natl Acad Sci U S A. 2023 Oct 3;120(40):e2310862120. PMID: 37756332

T cell receptor signaling strength establishes the chemotactic properties of effector CD8+ T cells that control tissue-residency

Abdelbary M, Hobbs SJ, Gibbs JS, Yewdell JW, Nolz JC.

Nat Commun. 2023 Jul 4;14(1):3928. doi: 10.1038/s41467-023-39592-1.PMID: 37402742

Viruses inhibit TIR gcADPR signalling to overcome bacterial defence

Leavitt A, Yirmiya E, Amitai G, Lu A, Garb J, Herbst E, Morehouse BR, Hobbs SJ, Antine SP, Sun ZJ, Kranzusch PJ, Sorek R.

Nature. 2022 Nov;611(7935):326-331. PMID: 36174646

Phage anti-CBASS and anti-Pycsar nucleases subvert bacterial immunity

Hobbs SJ, Wein T, Lu A, Morehouse BR, Schnabel J, Leavitt A, Yirmiya E, Sorek R, Kranzusch PJ.

Nature. 2022 May;605(7910):522-526. PMID: 35395152

Transcriptional regulator-induced phenotype screen reveals drug potentiators in Mycobacterium tuberculosis

Ma S, Morrison R, Hobbs SJ, Soni V, Farrow-Johnson J, Frando A, Fleck N, Grundner C, Rhee KY, Rustad TR, Sherman DR.

Nat Microbiol. 2021 Jan;6(1):44-50. PMID: 33199862

Vaccinia Virus Vectors Targeting Peptides for MHC Class II Presentation to CD4+ T Cells

Hobbs SJ, Harbour JC, Yates PA, Ortiz D, Landfear SM, Nolz JC.

Immunohorizons. 2020 Jan 2;4(1):1-13. PMID: 31896555

Targeted Expansion of Tissue-Resident CD8+ T Cells to Boost Cellular Immunity in the Skin

Hobbs SJ, Nolz JC.

Cell Rep. 2019 Dec 3;29(10):2990-2997.e2. PMID: 31801067

Central memory CD8+ T cells become CD69+ tissue-residents during viral skin infection independent of CD62L-mediated lymph node surveillance

Osborn JF, Hobbs SJ, Mooster JL, Khan TN, Kilgore AM, Harbour JC, Nolz JC.

PLoS Pathog. 2019 Mar 15;15(3):e1007633. PMID: 30875408

Activation and trafficking of CD8+ T cells during viral skin infection: immunological lessons learned from vaccinia virus

Hobbs SJ, Osborn JF, Nolz JC.

Curr Opin Virol. 2018 Feb;28:12-19. PMID: 29080420

Enzymatic synthesis of core 2 O-glycans governs the tissue-trafficking potential of memory CD8+ T cells

Osborn JF, Mooster JL, Hobbs SJ, Munks MW, Barry C, Harty JT, Hill AB, Nolz JC.

Sci Immunol. 2017 Oct 13;2(16):eaan6049. doi: 10.1126/sciimmunol.aan6049.PMID: 29030501

Regulation of T Cell Trafficking by Enzymatic Synthesis of O-Glycans

Hobbs SJ, Nolz JC.Front Immunol. 2017 May 24;8:600. PMID: 28596771

Role of neurokinin B in the control of female puberty and its modulation by metabolic status

Navarro VM, Ruiz-Pino F, Sánchez-Garrido MA, García-Galiano D, Hobbs SJ, Manfredi-Lozano M, León S, Sangiao-Alvarellos S, Castellano JM, Clifton DK, Pinilla L, Steiner RA, Tena-Sempere M.

J Neurosci. 2012 Feb 15;32(7):2388-97. PMID: 22396413